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Hypotheses 143:110102

This association is further supported by findings in suicidal MDD patients and first-degree relatives of BPD patients, where HDL-C depletion coincides with cognitive deficits and neuroprogression ( HDL dysfunction disrupts lipid raft integrity in neuronal membranes, altering serotonin receptor (5-HT1A) trafficking and monoamine signaling ( 3.1.2.3 LDL VLDL (very low-density lipoprotein), which is predominantly synthesized and secreted by the liver, contains apoB-100 as its primary structural apoprotein

Gut-educated immune cells can directly migrate into the CNS, enabling them to interact with brain-resident cells

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease